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Health Effects Assessment Summary (HEAST) for

Dinitrobenzene, 1,3-

CAS: 000099-65-0

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]: 1E-3 mg/kg/day
Uncertainty Factor: 100

Route: Oral: drinking water

Target Organ / Critical Effect: Spleen / Increased weight

Species Effect Level Dose
Rat NOAEL 0.4 mg/kg/day

References
1981 Cody T.E., S. Witherup, L. Hastings, K. Stemmer and R.T. Christian. 1981. 1,3-Dinitrobenzene. Toxic effect in vivo and in vitro. J Toxicol Environ Health. 7(5): 829-847.
1988 U.S. EPA. 1988. RfD/RfC Work Group.


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