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Health Effects Assessment Summary (HEAST) for

Di-n-Octyl Phthalate

CAS: 000117-84-0

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:on-Line
Subchronic [RfD]:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]: 2E-2 mg/kg/day
Uncertainty Factor: 1000

Subchronic [RfD]: 2E-2 mg/kg/day
Uncertainty Factor: 1000

Route: Oral: diet

Target Organ / Critical Effect: Kidney / Increased weight
Liver / Increased weight
Liver / Increased SGOT activity
Liver / Increased SGPT activity

Species Effect Level Dose Experiment Length
Rat LOAEL 175 mg/kg/day 7-12 months

References
1971 Piekacz H. 1971. Effect of Dioctyl and Dibutyl Phthalates on the organism of rats after oral administration in prolonged experiment. II. Subacute and Chronic Toxicity. Rocz Panstw Zakl Hig. 22(3): 295-307.
1987 U.S. EPA. 1987. Health and environmental effects profile for Phthalic Acid, Alkyl, Aryl, and Alkyl/Aryl Esters. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste, Washington, DC


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