HEAST Summary

Health Effects Assessment Summary (HEAST) for
Dimethylformamide, n,n-

CAS: 000068-12-2

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity

Chronic [RfD]: on-Line

Subchronic [RfD]: on-Line

Chronic [RfC]: IRIS

Subchronic [RfC]: on-Line

Notes/Comments: on-Line


Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]:	1E-1 mg/kg/day
Uncertainty Factor:	1000

Subchronic [RfD]:	1E+0 mg/kg/day
Uncertainty Factor:	100

Route:	Oral: diet

Target Organ / Critical Effect:	Liver / Effects

Species	Effect Level	Dose	Experiment Length
Rat	NOAEL	96 mg/kg/day	119 days

References
1983	Becci P.J., K.A. Voss, W.D. Johnson, et al. 1983. Subchronic feeding study of n,n-Dimethylformamide in rats and mice. J Am Coll Toxicol. 2(6): 371-378.
1986	U.S. EPA. 1986. Health and environmental effects profile for n,n-Dimethylformamide. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH, for the Office of Solid Waste and Emergency Response, Washington, DC


Subchronic [RfC]: (see comment)	3E-2 mg/cu m

Uncertainty Factor:	300

Route:	Inhalation: intermittent

Target Organ / Critical Effect:	Liver / Effects
	Gastrointestinal system / Effects

Species	Effect Level	Dose
Human	LOAEL	22 mg/cu m

References
1984	Cirla A.M., G. Pisati, E. Invernizzi et al. 1984. Epidemiological study on workers exposed to low Dimethylformamide concentrations. G Ital Med Lav. 6: 149-156.
1984	Catenacci G., D. Grampella, R. Terzi, et al. 1984. Hepatic function in subjects exposed to environmental concentrations of DMF lower than the actually proposed TLV. G Ital Medlav. 6: 157-158.
1990	U.S. EPA. 1990. RfD/RfC Work Group.

Subchronic [RfC] Comments:	The chronic inhalation RfC was adopted as the subchronic inhalation [RfC].

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