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Health Effects Assessment Summary (HEAST) for

Diethylene Glycol Monoethyl Ether

CAS: 000111-90-0

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:on-Line
Subchronic [RfD]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]: 5E+0 mg/kg/day
Uncertainty Factor: 100

Route: Oral: diet

Target Organ / Critical Effect: Kidney / Impaired function
Testis / Increased weight

Species Effect Level Dose Experiment Length
Rat NOEL 500 mg/kg/day 90 days

References
1966 Hall D.E., F.S. Lee, P. Austin and F.A. Fairweather. 1966. Short-term feeding study with Diethylene Glycol Monoethyl Ether in rats. Food Cosmet Toxicol. 4: 263.
1984 U.S. EPA. 1984. Health effects assessment for Glycol Ethers. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC EPA 540/1-86-052.




Chronic [RfD]:
(see comment)		 2E+0 mg/kg/day

Uncertainty Factor: 100

Route: Oral: drinking water

Target Organ / Critical Effect: Kidney / Histopathology

Species Effect Level Dose
Rat NOEL 200 mg/kg/day

References
1964 Smyth H.F., C.P. Carpenter and C.B. Shaffer. 1964. A 2-year study of Diethylene Glycol Monoethyl Ether in rats. Food Cosmet Toxicol. 2: 641-642.
1984 U.S. EPA. 1984. Health effects assessment for Glycol Ethers. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC EPA 540/1-86-052.
Chronic [RfD] Comments: Based on a 3-generation reproduction study.


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