|
|
|
|
Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
|
| Subchronic [RfD]: |
8E+0 mg/kg/day |
| Uncertainty Factor: |
100 |
|
| Route: |
Oral: diet |
|
| Target Organ / Critical Effect: |
Whole body / Decreased growth |
|
Organs / Decreased weight |
|
| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
NOAEL |
750 mg/kg/day |
16 weeks |
|
| References |
| 1978 | Brown D., K.R. Butterworth, I.F. Gaunt et al. 1978. Short-term oral toxicity study of Diethyl Phthalate in the rat. Food Cosmet Toxicol. 16: 415-422. |
| 1987 | U.S. EPA. 1987. Health effects assessment for selected Phthalic Acid Esters. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC |
| 1991 | U.S. EPA. 1991. Drinking water criteria document for Phthalic Acid Esters (PAE)s. Prepared by the Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Cincinnati, OH, for the Office of Drinking Water, Washington, DC |
| 1987 | U.S. EPA. 1987. RfD/RfC Work Group. |
|
