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Health Effects Assessment Summary (HEAST) for

Dieldrin

CAS: 000060-57-1

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:IRIS
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:IRIS
Inhalation [Unit Risk]:IRIS
EPA Group:IRIS
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 5E-5 mg/kg/day

Uncertainty Factor: 100

Route: Oral: diet

Target Organ / Critical Effect: Liver / Lesions

Species Effect Level Dose Experiment Length
Rat NOAEL 0.005 mg/kg/day 2 years

References
1969 Walker A.I.T., D.E. Stevenson, J. Robinson, et al. 1969. The toxicology and pharmacodynamics of Dieldrin (HEOD): Two-year oral exposure of rats and dogs. Toxicol Appl Pharmacol. 15: 345-373.
1987 U.S. EPA. 1987. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].





Carcinogenicity
Inhalation [Slope Factor]:
(see comment)		1.6E+1 (mg/kg/day)-1


Route: Oral: diet

Target Organ / Cancer: Liver / Carcinoma

Species EPA Group
Mouse IRIS

References
1978 NCI (National Cancer Institute). 1978. Bioassays of Aldrin and Dieldrin for possible carcinogenicity. National Cancer Institute Carcinogen Tech Rep Ser No. 22 NCI-CG-TR-22. Also publ as DHEW Publ No. (NIH) 78-882.
1972 Walker, A.I.T., E. Thorpe and D.E. Stevenson. 1972. The toxicology of Dieldrin (HEOD): I. Long-term oral toxicity studies in mice. Food Cosmet Toxicol. 11: 415-432.
1983 Meierhenrey, E.F., B.H. Reuber, M.E. Gershwin et al. 1983. Dieldrin induced mallory bodies in hepatic tumors of mice of different strains. Hepatology. 3: 90-95.
1981 Tennekes, H.A., A.S. Wright, K.M. Dix and J.H. Koeman. 1981. Effects of Dieldrin, diet and bedding on enzyme function and tumor incidence in livers of male CF-1 mice. Cancer Res. 41: 3615-3620.
1973 Thorpe, E. and A.I.T. Walker. 1973. The toxicology of Dieldrin (HEOD). II. Comparative long-term oral toxicity studies in mice with Dieldrin, DDT, Phenobarbitone, beta-BHC and gamma-BHC. Food Cosmet Toxicol. 11: 433-442.
1965 Davis, K.J. 1965. Pathology report on mice fed Aldrin, Dieldrin, Heptachlor or Hepatochlor epoxide for two years. Internal FDA memorandum to Dr. A.J. Lehman, July 19.
1987 U.S. EPA. 1987. Health effects assessment for Dieldrin. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC.
1987 U.S. EPA. 1987. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
Inhalation Slope Comment: See Appendix A-II, Dose Conversions on HEAST.


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