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Health Effects Assessment Summary (HEAST) for

Dicyclopentadiene

CAS: 000077-73-6

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:on-Line
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Alternative Methods
Chronic [RfC]:on-Line
Subchronic [RfC]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]:
(see comment)		 3E-2 mg/kg/day

Uncertainty Factor: 1000

Subchronic [RfD]:
(see comment)		 3E-1 mg/kg/day

Uncertainty Factor: 100

Route: Oral: diet

Target Organ / Critical Effect: None observed

Species Effect Level Dose Experiment Length
Rat NOEL 32 mg/kg/day 3 generations

References
1980 Litton Bionetics, Inc. 1980. Mammalian toxicological evaluation of DIMP and DCPD, (Phase 2). Litton Bionetics, Inc., Kensington, MD Contract Damb. 17-77-C-7003. NTIS AD-A082685.
1987 U.S. EPA. 1987. Health and environmental effects document for Cyclopentadiene and Dicyclopentadiene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
Subchronic [RfD] Comments: Based on a 3-generation reproduction study.
Chronic [RfD] Comments: Based on a 3-generation reproduction study.





Alternate Methods -- Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfC]:
(see comment)		 2E-4 mg/cu m

Uncertainty Factor: 10000

Subchronic [RfC]:
(see comment)		 2E-3 mg/cu m

Uncertainty Factor: 1000

Route: Inhalation: intermittent

Target Organ / Critical Effect: Kidney / Dysfunction

Species Effect Level Dose Experiment Length
Rat LOAEL 1 ppm 90 days

References
1982 Dodd D.E., L.C. Longo and D.L. Eisler. 1982. Dicyclopentadiene vapor ninety-day inhalation study on rats and mice. Bushy Run Research Center, Export, PA, TSCA 8E submission by Exxon Chem Amer Doc ID 88-8300464, ODD Doc ID 8EHQ-0283-0364, Microfiche No. OTS204864.
1987 U.S. EPA. 1987. Health and environmental effects document for Cyclopentadiene and Dicyclopentadiene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
Subchronic [RfC] Comments: 6E-4 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST).
Chronic [RfC] Comments: 6E-5 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST).
General Comments: The subchronic and chronic inhalation [RfC] values were derived from methodology that is not current with the interim inhalation methodology used by the RfD/RfC work group.


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