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Health Effects Assessment Summary (HEAST) for

Dichloropropene, 1,3- / (Telone II)

CAS: 000542-75-6

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Chronic [RfC]:IRIS
Subchronic [RfC]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:on-Line
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:on-Line
Inhalation [Unit Risk]:on-Line
EPA Group:IRIS
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]: 3E-3 mg/kg/day
Uncertainty Factor: 1000

Route: Oral: diet

Target Organ / Critical Effect: Organs / Increased weight

Species Effect Level Dose Experiment Length
Rat NOEL 3 mg/kg/day 90 days

References
1973 Dow Chemical Co. 1973. MRID Nos. 00067977, 0039684. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
1989 U.S. EPA. 1989. Health and environmental effects document for 1,3-Dichloropropene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
1987 U.S. EPA. 1987. RfD/RfC Work Group.
1993 U.S. EPA. 1993. Revised and updated drinking water quantification of toxicologic effects for 1,3-Dichloropropene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water, Washington, DC




Subchronic [RfC]:
(see comment)		 2E-2 mg/cu m

Uncertainty Factor: 30

Route: Inhalation: intermittent

Target Organ / Critical Effect: Nasal mucosa / Hypertrophy
Nasal mucosa / Hyperplasia

Species Effect Level Dose Experiment Length
Mouse NOAEL 5 ppm 2 years

References
1989 Lomax L.G., W.T. Stott, K.A. Johnson, et al. 1989. The chronic toxicity and oncogenicity of inhaled technical-grade 1,3-Dichloropropene in rats and mice. Fund Appl Toxicol. 10: 214.
1989 U.S. EPA. 1989. Health and environmental effects document for 1,3-Dichloropropene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
1990 U.S. EPA. 1990. RfD/RfC Work Group.
Subchronic [RfC] Comments: The chronic inhalation RfC was adopted as the subchronic inhalation [RfC].





Carcinogenicity
Inhalation [Slope Factor]:
(see comment)		1.3E-1 (mg/kg/day)-1


Inhalation [Unit Risk]: 3.7E-5 (µg/m3)-1

Route: Inhalation: intermittent

Target Organ / Cancer: Lung / Adenoma

Species Experiment Length EPA Group
Mouse 2 years IRIS

References
1989 Lomax L.G., W.T. Stott, K.A. Johnson, L.L. Calhoun, B.L. Yano and J.F. Quast. 1989. The chronic toxicity and oncogenicity of inhaled technical grade 1,3-Dichloropropene in rats and mice. Fund Appl Toxicol. 12: 418-431.
1989 U.S. EPA. 1989. Health and environmental effects document for 1,3-Dichloropropene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
1987 U.S. EPA. 1987. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
Inhalation Slope Comment: See Appendix A-II: Dose Conversions on HEAST.




Oral [Slope Factor]:
(see comment)		 1.8E-1 (mg/kg/day)-1


Oral [Unit Risk]: 5E-6 (µg/L)-1

Route: Oral: gavage

Target Organ / Cancer: Bladder / Carcinoma
Respiratory system / Alveolar/bronchiolar adenoma
Forestomach / Papilloma/carcinoma

Species Experiment Length EPA Group
Mouse 104 weeks IRIS

References
1985 NTP (National Toxicology Program). 1985. Toxicology and carcinogenesis studies of Telone II in F344/N rats and B6C3F1 mice. U.S. Dept Health and Human Services, Tech Report Ser No. 269.
1993 U.S. EPA. 1993. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
1993 U.S. EPA. 1993. Revised and updated drinking water quantification of toxicologic effects for 1,3-Dichloropropene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water, Washington, DC.
Oral Slope Comment: The [slope] is the geometric mean of slope factors of combined tumors listed.




Route: Oral: gavage

Target Organ / Cancer: Liver / Neoplastic nodule/carcinoma
Forestomach / Papilloma/carcinoma

Species Experiment Length
Rat 104 weeks

References
1985 NTP (National Toxicology Program). 1985. Toxicology and carcinogenesis studies of Telone II in F344/N rats and B6C3F1 mice. U.S. Dept Health and Human Services, Tech Report Ser No. 269.
1993 U.S. EPA. 1993. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
1993 U.S. EPA. 1993. Revised and updated drinking water quantification of toxicologic effects for 1,3-Dichloropropene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water, Washington, DC.


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