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Health Effects Assessment Summary (HEAST) for

Dichloropropane, 1,2-

CAS: 000078-87-5

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfC]:IRIS
Subchronic [RfC]:on-Line
Carcinogenicity
Oral [Slope Factor]:on-Line
Oral [Unit Risk]:on-Line
EPA Group:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfC]: 1.3E-2 mg/cu m
Uncertainty Factor: 100

Route: Inhalation: intermittent

Target Organ / Critical Effect: Nasal mucosa / Hyperplasia

Species Effect Level Dose Experiment Length
Rat NOAEL 69.3 mg/cu m 13 weeks

References
1988 Nitschke K.D., K.A. Johnson, D.L. Wackerle, J.E. Phillips, D.A. Dittenber. 1988. Propylene Dichloride: A 13 week inhalation toxicity study with rats, mice and rabbits. Dow Chemical Co, Mammalian and Environmental Toxicology Research Laboratory, Midland, MI.
1985 U.S. EPA. 1985. Health and environmental effects profile for Dichloropropanes. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
1991 U.S. EPA. 1991. RfD/RfC Work Group.





Carcinogenicity
Oral [Slope Factor]:
(see comment)		 6.8E-2 (mg/kg/day)-1


Oral [Unit Risk]: 1.9E-6 (µg/L)-1

Route: Oral: gavage

Target Organ / Cancer: Liver / Tumors

Species EPA Group
Mouse B2

References
1986 NTP (National Toxicology Program). 1986. NTP technical report on the carcinogenesis studies of 1,2-Dichloropropane (Propylene Dichloride). (CAS No. 78-87-5) in F344/N rats and B6C3F1 mice (gavage studies). NTP-82-092, NIH publ No. 84-2519, NTP TR 263. U.S. DHHS, PHS, NIH. August, 1986 draft.
1987 U.S. EPA. 1987. Health effects assessment for 1,2-Dichloropropane. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH, for the Office of Solid Waste and Emergency Response, Washington, DC.
Oral Slope Comment: Under review, number subject to change.


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