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Health Effects Assessment Summary (HEAST) for

Dichloroethylene, 1,2-cis-

CAS: 000156-59-2

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:on-Line
Subchronic [RfD]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]:
(see comment)		 1E-2 mg/kg/day

Uncertainty Factor: 3000

Subchronic [RfD]: 1E-1 mg/kg/day
Uncertainty Factor: 300

Route: Oral: gavage

Target Organ / Critical Effect: Blood / Decreased hematocrit
Blood / Decreased hemoglobin

Species Effect Level Dose Experiment Length
Rat NOAEL 32 mg/kg/day 90 days

References
McCauley P.T., M. Robinson, L.W. Condie, et al. No date. The effects of subacute and subchronic oral exposure to cis-1,2-Dichloroethylene in rats. Health Effects Research Laboratory, U.S. EPA, Cincinnati, OH.
1984 U.S. EPA. 1984. Health effects assessment for 1,2-c-Dichloroethylene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC
1990 U.S. EPA. 1990. RfD/RfC Work Group.
Chronic [RfD] Comments: Under review, current number subject to change.


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