Health Effects Assessment Summary (HEAST) for
Dichloroethylene, 1,2- (Mixed Isomers)
CAS: 000540-59-0
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Chronic [RfD]: (see comment) |
9E-3 mg/kg/day | |||
| Uncertainty Factor: | 1000 | |||
| Subchronic [RfD]: (see comment) |
9E-3 mg/kg/day | |||
| Uncertainty Factor: | 1000 | |||
| Route: | Oral: drinking water | |||
| Target Organ / Critical Effect: | Liver / Lesions | |||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | LOAEL | 50 ppm | 2 years | |
| References | ||||
| 1983 | Quast, JF, C.G. Humiston, C.E. Wade, et al. 1983. A chronic toxicity and oncogenicity study in rats and subchronic toxicity study in dogs on ingested Vinylidine Chloride. Fund Appl Toxicol. 3: 55-62. | |||
| 1991 | U.S. EPA. 1991. Health and environmental effects document for 1,2-Dichloroethylene (mixed isomers). Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC | |||
| Subchronic [RfD] Comments: | Values derived for 1,1-dichloroethylene were adopted for 1,2- dichloroethylene mixed isomers based on analogy. | |||
| Chronic [RfD] Comments: | Values derived for 1,1-Dichloroethylene (000075-35-4) were adopted for 1,2-Dichloroethylene mixed isomers based on analogy. | |||
[ Risk Assessment Home ]
[ EPA Home |
OSWER Home | Superfund Home ]
[ Search EPA
| Search Superfund
| Whats New |
Contact Us ]
URL: http://risk.lsd.ornl.gov/epa/heast/heast_select.htm
This page was last updated on: March 1, 2000
Site maintained by: Office of Emergency and Remedial Response
Hofmann.Lee@epamail.epa.gov