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Health Effects Assessment Summary (HEAST) for

Dichloroethylene, 1,1-

CAS: 000075-35-4

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:IRIS
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:IRIS
Inhalation [Unit Risk]:IRIS
EPA Group:IRIS
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 9E-3 mg/kg/day

Uncertainty Factor: 1000

Route: Oral: drinking water

Target Organ / Critical Effect: Liver / Lesions

Species Effect Level Dose Experiment Length
Rat LOAEL 9 mg/kg/day 2 years

References
1983 Quast J.F., C.G. Humiston, C.E. Wade, et al. 1983. A chronic toxicity and oncogenicity study in rats and subchronic toxicity study in dogs on ingested Vinylidene Chloride. Fund Appl Toxicol. 3(1): 55-62.
1988 U.S. EPA. 1988. Updated health effects assessment for 1,1-Dichloroethylene (Vinylidine Chloride). Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC
1989 U.S. EPA. 1989. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].





Carcinogenicity
Inhalation [Slope Factor]:
(see comment)		1.2E+0 (mg/kg/day)-1


Route: Inhalation

Target Organ / Cancer: Kidney / Adenocarcinoma

Species Experiment Length EPA Group
Mouse 12 months IRIS

References
1985 Maltoni, C., G. Lefemine, P. Chieco et al. 1985. Experimental research on Vinylidene Chloride carcinogenesis. In: Archives of research on industrial carcinogenesis, Vol 3, C. Maltoni and M. Mehlman, ed., Princeton Scientific Publishers, Princeton, NJ.
1985 U.S. EPA. 1985. Health assessment document for Vinylidene Chloride. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Research Triangle Park, NC.
1987 U.S. EPA. 1987. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
Inhalation Slope Comment: See Appendix A-II, Dose Conversions on HEAST.


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