HEAST Summary

Health Effects Assessment Summary (HEAST) for
Dichloroethane, 1,1-

CAS: 000075-34-3

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity

Chronic [RfD]: on-Line

Subchronic [RfD]: on-Line

Notes/Comments: on-Line

Alternative Methods

Chronic [RfC]: on-Line

Subchronic [RfC]: on-Line

Notes/Comments: on-Line

Carcinogenicity

EPA Group: IRIS


Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]: (see comment)	1E-1 mg/kg/day

Uncertainty Factor:	1000

Subchronic [RfD]: (see comment)	1E+0 mg/kg/day

Uncertainty Factor:	100

Route:	Inhalation: intermittent

Target Organ / Critical Effect:	None observed

Species	Effect Level	Dose	Experiment Length
Rat	NOEL	115 mg/kg/day	13 weeks

References
1971	Hofmann H.T., H. Birnstiel and P. Jobst. 1971. On the inhalation toxicity of 1,1- and 1,2-Dichloroethane. Arch Toxikol. 27: 248-265.
1984	U.S. EPA. 1984. Health effects assessment for 1,1-Dichloroethane. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC

Subchronic [RfD] Comments:	Based on route to route extrapolation.
Chronic [RfD] Comments:	Based on route to route extrapolation.


Alternate Methods -- Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfC]: (see comment)	5E-1 mg/cu m

Uncertainty Factor:	1000

Subchronic [RfC]: (see comment)	5E+0 mg/cu m

Uncertainty Factor:	100

Route:	Inhalation: intermittent

Target Organ / Critical Effect:	Kidney / Damage

Species	Effect Level	Dose	Experiment Length
Cat	NOEL	138 mg/kg/day	13 weeks

References
1971	Hofmann H.T., H. Birnstiel and P. Jobst. 1971. On the inhalation toxicity of 1,1- and 1,2-Dichloroethane. Arch Toxikol. 27: 248-265.
1984	U.S. EPA. 1984. Health effects assessment for 1,1-Dichloroethane. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC.

Subchronic [RfC] Comments:	1E+0 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST).
Chronic [RfC] Comments:	1E-1 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST).
General Comments:	The subchronic and chronic inhalation [RfC] values were derived from methodology that is not current with the interim inhalation methodology used by the RfD/RfC work group.

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This page was last updated on: March 1, 2000
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