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Health Effects Assessment Summary (HEAST) for

Dichlorodifluoromethane

CAS: 000075-71-8

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Alternative Methods
Chronic [RfC]:on-Line
Subchronic [RfC]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]: 9E-1 mg/kg/day
Uncertainty Factor: 100

Route: Oral: diet

Target Organ / Critical Effect: None observed

Species Effect Level Dose Experiment Length
Dog NOAEL 90 mg/kg/day 90 days

References
1967 Clayton W.J., Jr. 1967. Fluorocarbon toxicity and biological action. Fluorine Chem Rev. 1(2): 197-252.
1987 U.S. EPA. 1987. Health effects assessment for fully Halogenated Methanes. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC





Alternate Methods -- Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfC]:
(see comment)		 2E-1 mg/cu m

Uncertainty Factor: 10000

Subchronic [RfC]:
(see comment)		 2E+0 mg/cu m

Uncertainty Factor: 1000

Route: Inhalation: intermittent

Target Organ / Critical Effect: Liver / Lesions

Species Effect Level Dose Experiment Length
Guinea pig LOAEL 482.3 mg/kg/day 6 weeks

References
1967 Prendergast J.A., R.A. Jones, L.J. Jenkins and J. Siegal. 1967. Effects on experimental animals of long-term inhalation of Trichloroethylene, Carbon tetrachloride, 1,1,1-Trichloroethane, Dichlorodifluoromethane and 1,1-Dichloroethylene. Toxicol Appl Pharmacol. 10: 270-289.
1987 U.S. EPA. 1987. Health effects assessment for fully Halogenated Methanes. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC.
Subchronic [RfC] Comments: 5E-1 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST).
Chronic [RfC] Comments: 5E-2 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST).
General Comments: The subchronic and chronic inhalation [RfC] values were derived from methodology that is not current with the interim inhalation methodology used by the RfD/RfC work group.


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