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Health Effects Assessment Summary (HEAST) for

Dichlorobenzene, 1,4-

CAS: 000106-46-7

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfC]:IRIS
Subchronic [RfC]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:on-Line
Oral [Unit Risk]:on-Line
EPA Group:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfC]:
(see comment)		 2.5E+0 mg/cu m

Uncertainty Factor: 30

Route: Inhalation: intermittent

Target Organ / Critical Effect: Liver / Increased weight in male parents

Species Effect Level Dose Experiment Length
Rat NOAEL 75 mg/cu m Multi-generation

References
1986 Chlorobenzene Producers Assn. 1986. Paradichlorobenzene: Two-generation reproduction study in Sprague-Dawley rats. Study No. 86-81-90605. MRID No. 411088-1. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
1992 U.S. EPA. 1992. RfD/RfC Work Group.
1987 NTP (National Toxicology Program). 1987. Toxicology and carcinogenesis studies of 1,4-Dichlorobenzene in F344/N rats and B6C3F1 mice (gavage studies). NTP TR 319. NIH PUB NO 87-2575.
Subchronic [RfC] Comments: The chronic inhalation RfC was modified to estimate the subchronic inhalation [RfC].





Carcinogenicity
Oral [Slope Factor]:
(see comment)		 2.4E-2 (mg/kg/day)-1


Oral [Unit Risk]: 6.8E-7 (µg/L)-1

Route: Oral: gavage

Target Organ / Cancer: Liver / Tumors

Species Experiment Length EPA Group
Mouse 103 weeks C

References
1986 NTP (National Toxicology Program). 1986. Toxicology and carcinogenesis studies of 1,4-Dichlorobenzene in F344/N rats and B6C3F1 mice -- galley draft. U.S. DHHS, PHS, NIH Tech Rep Ser No. 319.
1987 Contaminants. 1987. FR(July 8). 52:25690-25717.
Oral Slope Comment: Under review, number subject to change.


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