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Health Effects Assessment Summary (HEAST) for

Dichlorobenzene, 1,2-

CAS: 000095-50-1

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Alternative Methods
Chronic [RfC]:on-Line
Subchronic [RfC]:on-Line
Notes/Comments:on-Line





Alternate Methods -- Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfC]:
(see comment)		 2E-1 mg/cu m

Uncertainty Factor: 1000

Subchronic [RfC]: 2E+0 mg/cu m
Uncertainty Factor: 100

Route: Inhalation: intermittent

Target Organ / Critical Effect: Whole body / Decreased weight gain

Species Effect Level Dose Experiment Length
Rat NOEL 49 ppm Up to 7 months

References
1958 Hollingsworth R.L., V.K. Rowe, F. Oyen, T.R. Torkelson and E.M. Adams. 1958. Toxicity of o-Dichlorobenzene. Am Med Assoc Arch Ind Health. 17(1): 180-187.
1987 U.S. EPA. 1987. Health effects assessment for Dichlorobenzenes. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC.
Chronic [RfC] Comments: 4E-2 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST).
General Comments: The subchronic and chronic inhalation [RfC] values were derived from methodology that is not current with the interim inhalation methodology used by the RfD/RfC work group.


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