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Health Effects Assessment Summary (HEAST) for

Dicamba

CAS: 001918-00-9

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 3E-2 mg/kg/day

Uncertainty Factor: 100

Route: Oral: gavage

Target Organ / Critical Effect: Fetus / Decreased weight
Fetus / Increased post-implantation losses
Fetus / Increased mortality
Dam / Decreased weight gain

Species Effect Level Dose Experiment Length
Rabbit NOAEL 3 mg/kg/day Gestation days 6-18

References
1978 Goldenthal E.I., D.C. Jessup and D.E. Rodwell. 1978. Teratology study in rabbits: IRDC No. 163-436. (unpublished study received March 6, 1979 under 876-36. Prepared by International Research and Development Corp., Submitted by Velsicol Chemical Corp., Chicago, IL. CDL:237995-E). Cited as Velsicol Chemical Corporation (1978) in U.S. EPA (1993). MRID 00028236. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
1993 U.S. EPA. 1993. Revised and updated drinking water quantification of toxicologic effects for Dicamba. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water, Washington, DC
1988 U.S. EPA. 1988. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].


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