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Health Effects Assessment Summary (HEAST) for

Dibromoethane, 1,2-

CAS: 000106-93-4

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfC]:on-Line
Subchronic [RfC]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:IRIS
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:IRIS
Inhalation [Unit Risk]:IRIS
EPA Group:IRIS
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfC]:
(see comment)		 2E-4 mg/cu m

Uncertainty Factor: 1000

Subchronic [RfC]:
(see comment)		 2E-3 mg/cu m

Uncertainty Factor: 100

Route: Inhalation: intermittent

Target Organ / Critical Effect: Sperm / Effects

Species Effect Level Dose
Human LOAEL 88 ppb

References
1987 Ratcliffe J.M., S.M. Schrader, K. Steenland, D.E. Clapp, T. Turner and R.W. Hornung. 1987. Semen quality in papaya workers with long-term exposure to Ethylene Bromide. Br J Ind Med. 44: 317-326.
1988 Schrader S.M., T.W. Turner and J.M. Ratcliffe. 1988. The effects of Ethylene Bromide on semen quality: A comparison of short-term and chronic exposure. Reprod Toxicology. 2: 191-198.
1992 U.S. EPA. 1992. RfD/RfC Work Group.
Subchronic [RfC] Comments: The chronic inhalation [RfC] was modified to estimate the subchronic inhalation [RfC].
Chronic [RfC] Comments: Under review, current number subject to change.





Carcinogenicity
Inhalation [Slope Factor]:
(see comment)		7.6E-1 (mg/kg/day)-1


Route: Inhalation: intermittent

Target Organ / Cancer: Nasal cavity / Tumors

Species Experiment Length EPA Group
Rat 88-103 weeks IRIS

References
1982 NTP (National Toxicology Program). 1982. Carcinogenesis bioassay of 1,2-Dibromoethane (Ethylene Dibromide) (CAS No. 106-93-4) in F344 rats and B6C3F1 mice (inhalation study). NTP Tech Rep Ser No. 210, NIH Publ No. 82-1766.
1987 U.S. EPA. 1987. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
Inhalation Slope Comment: See Appendix A-II, Dose Conversions on HEAST.


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