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Health Effects Assessment Summary (HEAST) for

Dibromo-3-Chloropropane, 1,2-

CAS: 000096-12-8

Summary of HEAST Information on-Line

Carcinogenicity
Oral [Slope Factor]:on-Line
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:on-Line
Inhalation [Unit Risk]:on-Line
EPA Group:on-Line
Notes/Comments:on-Line





Carcinogenicity
Oral [Slope Factor]: 1.4E+0 (mg/kg/day)-1

Oral [Unit Risk]: 4E-5 (µg/L)-1

Route: Oral: diet

Target Organ / Cancer: Stomach / Tumors
Kidney / Tumors
Liver / Tumors

EPA Group
B2

References
1977 Hazelton Laboratories, Inc. 1977. 104 week dietary study in rats, 1,2-Dibromo-3-chloropropane (DBCP). Final report. Unpublished report submitted to Dow Chemical Co., Midland, MI. October 29, 1977.
1988 U.S. EPA. 1988. Drinking water criteria document for Dibromochloropropane. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Drinking Water, Washington, DC. ECAO-CIN-410.
1988 U.S. EPA. 1988. Assessment of the carcinogenic potential of 1,2-Dibromo-3-chloropropane (DBCP). Prepared by the Carcinogen Assessment Group. Available through RCRA/Superfund docket.
EPA Group Comment: Under review, classification subject to change.




Inhalation [Slope Factor]: 2.4E-3 (mg/kg/day)-1

Inhalation [Unit Risk]:

Route: Inhalation: intermittent

Target Organ / Cancer: Nasal cavity / Tumors

Species EPA Group
Rat, Mouse B2

References
1982 NTP (National Toxicology Program). 1982. Carcinogenesis bioassay of 1,2-Dibromo-3-chloropropane (CAS No. 96-12-8) in F344 rats and B6C3F1 mice (inhalation study). NTP-TR-NO 81-21.
1989 U.S. EPA. 1989. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.


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