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Health Effects Assessment Summary (HEAST) for

Decabromodiphenyl Ether

CAS: 001163-19-5

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
EPA Group:IRIS





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 1E-2 mg/kg/day

Uncertainty Factor: 100

Route: Oral: diet

Target Organ / Critical Effect: Liver / Increased weight

Species Effect Level Dose Experiment Length
Rat NOEL 1 mg/kg/day 2 years

References
1975 Kociba R.J., L.O. Frauson, C.G. Humiston, et al. 1975. Results of a two-year dietary feeding study with Decabromodiphenyloxide (DCDPO) in rats. Combust Toxicol. 2(4): 267-285.
1975 Norris J.M., J.W. Ehrmantraut, C.L. Gibbons, et al. 1975. Toxicology of Octabromobiphenyl and Decabromodiphenyl Oxide. Environ Health Perspect. 11: 153-161.
1984 U.S. EPA. 1984. Health and environmental effects profile for Brominated Diphenyl Ether. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
1985 U.S. EPA. 1985. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].


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