Health Effects Assessment Summary (HEAST) for
Dalapon
CAS: 000075-99-0
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Subchronic [RfD]: (see comment) |
3E-2 mg/kg/day | |||
| Uncertainty Factor: | 300 | |||
| Route: | Oral: diet | |||
| Target Organ / Critical Effect: | Kidney / Increased relative weight | |||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | NOEL | 8.45 mg/kg/day | 2 years | |
| References | ||||
| 1960 | Paynter O.E., T.W. Tusing, D.D. McCollister and V.K. Rowe. 1960. Toxicology of Dalapon Sodium (2,2-Dichloropropionic Acid, Sodium Salt). J Agric Food Chem. 8: 47-51. | |||
| 1984 | U.S. EPA. 1984. Health and environmental effects profile for Dalapon. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC | |||
| 1988 | U.S. EPA. 1988. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | Calculated by analogy to dalapon sodium by correcting for differences in molecular weight. The chronic oral RfD was adopted as the subchronic oral [RfD]. | |||
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