HEAST Summary

Health Effects Assessment Summary (HEAST) for
DDT

CAS: 000050-29-3

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity

Chronic [RfD]: IRIS

Subchronic [RfD]: on-Line

Notes/Comments: on-Line

Carcinogenicity

Oral [Slope Factor]: IRIS

Inhalation [Slope Factor]: on-Line

Oral [Unit Risk]: IRIS

Inhalation [Unit Risk]: IRIS

EPA Group: IRIS

Notes/Comments: on-Line


Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]: (see comment)	5E-4 mg/kg/day

Uncertainty Factor:	100

Route:	Oral: diet

Target Organ / Critical Effect:	Liver / Lesions

Species	Effect Level	Dose	Experiment Length
Rat	NOEL	0.05 mg/kg/day	27 weeks

References
1950	Laug, E.P., A.A. Nelson, O.G. Fitzhugh and F.M. Kunze. 1950. Liver cell alteration and DDT storage in the fat of the rat induced by dietary levels of 1-50 ppm DDT. J Pharmacol Exp Therap. 98: 268-273.
1985	U.S. EPA. 1985. RfD/RfC Work Group.

Subchronic [RfD] Comments:	The chronic oral RfD was adopted as the subchronic oral [RfD].


Carcinogenicity

Inhalation [Slope Factor]: (see comment)	3.4E-1 (mg/kg/day)^-1


Route:	Oral: diet

Target Organ / Cancer:	Liver / Tumors

Species	EPA Group
Mouse, Rat	IRIS

References
1986	U.S. EPA. 1986. The Carcinogen Assessment Group's evaluation of the carcinogenicity of Dicofol (Kelthane), DDT, DDE, and DDD (TDE). Prepared by the Office of Health and Environmental Assessment, Carcinogen Assessment Group, Washington, DC, for the Hazard Evaluation Division, Office of Pesticide Programs, Office of Pesticides and Toxic Substances, Washington, DC.
1988	U.S. EPA. 1988. Updated health effects assessment for DDT. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC. EPA 540/1-86-026.
1987	U.S. EPA. 1987. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.

Inhalation Slope Comment:	Based on route to route extrapolation. See Appendix A-II, Dose Conversions on HEAST.

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