Health Effects Assessment Summary (HEAST) for
Cyanogen Bromide
CAS: 000506-68-3
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Subchronic [RfD]: (see comment) |
9E-2 mg/kg/day | |||
| Uncertainty Factor: | 500 | |||
| Route: | Oral: diet | |||
| Target Organ / Critical Effect: | Whole body / Decreased weight | |||
| Thyroid / Effects | ||||
| Nerve / Myelin degeneration | ||||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | NOAEL | 44 mg/kg/day | 2 years | |
| References | ||||
| 1955 | Howard J.W. and R.F. Hanzal. 1955. Chronic toxicity for rats of food treated with Hydrogen Cyanide. Agric Food Chem. 3: 325-329. | |||
| 1987 | U.S. EPA. 1987. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | Calculated by analogy to free cyanide by correcting for differences in molecular weight. The chronic oral RfD was adopted as the subchronic oral [RfD]. | |||
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