Health Effects Assessment Summary (HEAST) for
Cyanide
CAS: 000057-12-5
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Subchronic [RfD]: (see comment) |
2E-2 mg/kg/day | |||
| Uncertainty Factor: | 500 | |||
| Route: | Oral: diet | |||
| Target Organ / Critical Effect: | Whole body / Decreased weight | |||
| Thyroid / Effects | ||||
| Nerve / Myelin degeneration | ||||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | NOAEL | 10.8 mg/kg/day | 104 weeks | |
| References | ||||
| 1955 | Howard J.W. and R.F. Hanzal. 1955. Chronic toxicity for rats of food treated with Hydrogen Cyanide. J Agric Food Chem. 3: 325-329. | |||
| 1984 | U.S. EPA. 1984. Health effects assessment for Cyanide. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC | |||
| 1991 | U.S. EPA. 1991. Drinking water criteria document for Cyanide. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Drinking Water, Washington, DC | |||
| 1985 | U.S. EPA. 1985. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | The chronic oral RfD was adopted as the subchronic oral [RfD]. | |||
| General Comments: | The casrn for CN- is 000057-12-5; the casrn for HCN- is 000074-90-8. | |||
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