HEAST Summary

Health Effects Assessment Summary (HEAST) for
Cyanazine

CAS: 021725-46-2

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity

Chronic [RfD]: on-Line

Subchronic [RfD]: on-Line

Notes/Comments: on-Line

Carcinogenicity

Oral [Slope Factor]: on-Line

Oral [Unit Risk]: on-Line

EPA Group: on-Line


Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]: (see comment)	2E-3

Uncertainty Factor:	300

Subchronic [RfD]: (see comment)	2E-3 mg/kg/day

Uncertainty Factor:	300

Route:	Oral: diet

Target Organ / Critical Effect:	Whole body / Decreased weight
	Blood / Increased platelet count
	Blood / Altered clinical chemistry parameters

Species	Effect Level	Dose	Experiment Length
Dog	NOEL	0.625 mg/kg/day	1 year

References
1986	E.I. Du Pont de Nemours and Company, Inc. 1986. Confidential business information, unpublished study. MRID No. 40081901 and 40229001. Available from EPA, write to FOI, EPA, Washington, DC 20460.
1984	U.S. EPA. 1984. Health and environmental effects profile for Cyanazine. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste, Washington, DC
1992	U.S. EPA. 1992. RfD/RfC Work Group.
1993	U.S. EPA. 1993. Revised and updated drinking water quantification of toxicologic effects for Cyanazine. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water, Washington, DC

Subchronic [RfD] Comments:	The chronic oral [RfD] was adopted as the subchronic oral [RfD].
Chronic [RfD] Comments:	The chronic oral RfD was withdrawn from IRIS (07/01/92). Under review, current number subject to change.


Carcinogenicity

Oral [Slope Factor]:	8.4E-1 (mg/kg/day)^-1

Oral [Unit Risk]:	2.4E-5 (µg/L)^-1

Route:	Oral: diet

Target Organ / Cancer:	Mammary gland / Adenomas/carcinomas, combined

Species	Experiment Length	EPA Group
Rat	2 years	C

References
1990	Bogdanffy M.S. 1990. Combined chronic toxicity/oncogenicity study with Cyanazine (INR-1957) 2-year feeding study in rats. Prepared by E.I. Du Pont de Nemours and Co.
1993	U.S. EPA. 1993. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.

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