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Health Effects Assessment Summary (HEAST) for
Cumene
CAS: 000098-82-8
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Summary of HEAST Information on-Line
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| Subchronic and Chronic Toxicity |
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
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| Subchronic [RfD]: |
4E-1 mg/kg/day |
| Uncertainty Factor: |
300 |
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| Route: |
Oral: gavage |
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| Target Organ / Critical Effect: |
Kidney / Increased weight |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
NOAEL |
154 mg/kg/day |
194 days |
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| References |
| 1956 | Wolf M.A., V.K. Rowe, D.D. McCollister, R.L. Hollingsworth and F. Oyen. 1956. Toxicological studies of certain Alkylated Benzenes and Benzenes. AMA Arch Ind Health. 14: 387-398. |
| 1987 | U.S. EPA. 1987. Health and environmental effects document for Cumene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
| 1987 | U.S. EPA. 1987. RfD/RfC Work Group. |
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| Subchronic [RfC]: |
9E-2 mg/cu m |
| Uncertainty Factor: |
1000 |
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| Route: |
Inhalation: intermittent |
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| Target Organ / Critical Effect: |
Central nervous system / Involvement |
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Nose / Irritation |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
NOAEL |
105.1 ppm |
4 weeks |
|
| References |
| 1986 | Monsanto Company. 1986. One month study of Cumene vapor administered to male and female Sprague-Dawley rats by inhalation. U.S. EPA/OTS public files, 8D submission. Microfiche# OTS 0513229. |
| 1987 | U.S. EPA. 1987. Health and environmental effects document for Cumene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
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