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Health Effects Assessment Summary (HEAST) for

Cresol, p- / (4-Methylphenol)

CAS: 000106-44-5

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:on-Line
Subchronic [RfD]:on-Line
Chronic [RfC]:IRIS
Notes/Comments:on-Line
Carcinogenicity
EPA Group:IRIS





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]: 5E-3 mg/kg/day
Uncertainty Factor: 1000

Subchronic [RfD]:
(see comment)		 5E-3 mg/kg/day

Uncertainty Factor: 1000

Route: Oral: gavage

Target Organ / Critical Effect: Central nervous system / Hypoactivity
Respiratory system / Distress
Whole body / Maternal death

Species Effect Level Dose Experiment Length
Rabbit NOAEL 5 mg/(kg-day) Gestation days 6-18

References
1988 CMA (Chemical Manufacturers' Association). 1988. Developmental toxicity evaluation of o-, m- or p-Cresol administered by gavage to New Zealand white rabbits. Final project report 51-508. Fiche No. 0TS0517695.
1988 Deitz D., and L.T. Mulligan. 1988. Subchronic toxicity of p-Cresol in Sprague-Dawley rats: MBA chemical No. 25. Prepared by Research Triangle Institute, Research Triangle Park, NC. Prepared for EPA, Washington, DC
1993 U.S. EPA. 1993. RfD/RfC Work Group.
1990 U.S. EPA. 1990. Health and environmental effects document for p-Cresol. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
Subchronic [RfD] Comments: The chronic oral [RfD] was adopted as the subchronic oral [RfD].


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