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Health Effects Assessment Summary (HEAST) for

Chromium VI

CAS: 018540-29-9

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Carcinogenicity
Inhalation [Slope Factor]:on-Line
Inhalation [Unit Risk]:IRIS
EPA Group:IRIS
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]: 2E-2 mg/kg/day
Uncertainty Factor: 100

Route: Oral: drinking water

Target Organ / Critical Effect: None observed

Species Effect Level Dose Experiment Length
Rat NOAEL 2.4 mg/kg/day 1 year

References
1958 Mackenzie R.D., R.U. Byerrum, C.F. Decker et al. 1958. Chronic Toxicity Studies, II. Hexavalent and Trivalent Chromium administered in drinking water to rats. Am Med Assoc Arch Ind Health. 18: 232-234.
1984 U.S. EPA. 1984. Health effects assessment for Hexavalent Chromium. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC
1986 U.S. EPA. 1986. RfD/RfC Work Group.





Carcinogenicity
Inhalation [Slope Factor]:
(see comment)		4.1E+1 (mg/kg/day)-1


Route: Inhalation: occupational

Target Organ / Cancer: Lung / Tumors

Species EPA Group
Human IRIS

References
1975 Mancuso, T.F. 1975. International conference on heavy metals in the environment, Toronto, Canada, Oct 27-31. Cited in U.S. EPA, 1984.
1984 U.S. EPA. 1984. Health effects assessment for hexavalent Chromium. Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC.
1984 U.S. EPA. 1984. Health assessment document for Chromium. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the U.S. Environmental Protection Agency, Research Triangle Park, NC.
1986 U.S. EPA. 1986. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
Inhalation Slope Comment: See Appendix A-II, Dose Conversions on HEAST.


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