Health Effects Assessment Summary (HEAST) for
Chlorothalonil
CAS: 001897-45-6
| Summary of HEAST Information on-Line | ||||||||
| Subchronic and Chronic Toxicity | ||||||||
| ||||||||
| Carcinogenicity | ||||||||
|
| Subchronic [RfD]: (see comment) |
1.5E-2 mg/kg/day | |||
| Uncertainty Factor: | 100 | |||
| Route: | Oral: diet | |||
| Target Organ / Critical Effect: | Kidney / Effects | |||
| Species | Effect Level | Dose | Experiment Length | |
| Dog | NOEL | 1.5 mg/kg/day | 2 years | |
| References | ||||
| 1970 | Diamond Shamrock Chemical Company. 1970. Confidential business information, unpublished study. Accession NO 111253, MRID No. 00057702, 00114034. Available from EPA. Write to FOI, EPA, Washington, DC 20460. | |||
| 1986 | U.S. EPA. 1986. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | The chronic oral RfD was adopted as the subchronic oral [RfD]. | |||
| Oral [Slope Factor]: (see comment) |
1.1E-2 (mg/kg/day)-1 | |||
| Oral [Unit Risk]: | 3.1E-7 (µg/L)-1 | |||
| Route: | Oral: diet | |||
| Target Organ / Cancer: | Kidney / Tumor | |||
| Species | Experiment Length | EPA Group | ||
| Rat | 27-32 months | B2 | ||
| References | ||||
| 1985 | IRDC. 1985. Tumorigenicity study in rats. Chlorothalonil. 099-5tx-80-234-008. | |||
| 1984 | U.S. EPA. 1984. Health and environmental effects profile for Chlorothalonil. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. | |||
| Oral Slope Comment: | Under review, number subject to change. | |||
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