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Health Effects Assessment Summary (HEAST) for

Chloromethane / (Methyl Chloride)

CAS: 000074-87-3

Summary of HEAST Information on-Line

Carcinogenicity
Oral [Slope Factor]:on-Line
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:on-Line
Inhalation [Unit Risk]:on-Line
EPA Group:on-Line
Notes/Comments:on-Line





Carcinogenicity
Oral [Slope Factor]:
(see comment)		 1.3E-2 (mg/kg/day)-1


Inhalation [Slope Factor]: 6.3E-3 (mg/kg/day)-1

Oral [Unit Risk]: 3.7E-7 (µg/L)-1

Inhalation [Unit Risk]: 1.8E-6 (µg/m3)-1

Route: Inhalation: intermittent

Target Organ / Cancer: Kidney / Tumors

Species Experiment Length EPA Group
Mouse 24 months C

References
1981 CIIT (Chemical Industry Institute of Toxicology). 1981. Final report on 24-month inhalation study on Methyl chloride. Prepared by Battelle-Columbus Laboratories, Columbus, OH December 31.
1984 NIOSH (National Institute for Occupational Safety and Health). 1984. Carcinogenic risk assessment for occupational exposure to Monohalomethanes. NTIS PB85-111623.
1986 U.S. EPA. 1986. Health and environmental effects profile for Methyl Chloride. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
1987 U.S. EPA. 1987. Health effects assessment for Chloromethane. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC.
Oral Slope Comment: Based on route to route extrapolation.


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