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Health Effects Assessment Summary (HEAST) for

Chloroform

CAS: 000067-66-3

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:IRIS
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:IRIS
Inhalation [Unit Risk]:IRIS
EPA Group:IRIS
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 1E-2 mg/kg/day

Uncertainty Factor: 1000

Route: Oral: capsule

Target Organ / Critical Effect: Liver / Lesions

Species Effect Level Dose Experiment Length
Dog LOAEL 12.9 mg/kg/day 7.5 years

References
1987 U.S. EPA. 1987. Health and environmental effects document for Chlorinated Cyclopentidienes. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].





Carcinogenicity
Inhalation [Slope Factor]:
(see comment)		8.1E-2 (mg/kg/day)-1


Route: Oral: gavage

Target Organ / Cancer: Liver / Carcinoma

Species Experiment Length EPA Group
Mouse 78 weeks IRIS

References
1976 NCI (National Cancer Institute). 1976. Report on carcinogenesis bioassay of Chloroform. NTIS PB264-018.
1988 U.S. EPA. 1988. Updated health effects assessment for Chloroform. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC.
1985 U.S. EPA. 1985. Health assessment document for Chloroform. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Research Triangle Park, NC.
1987 U.S. EPA. 1987. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
Inhalation Slope Comment: Based on route to route extrapolation. See Appendix A-II, Dose Conversions on HEAST.


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