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Health Effects Assessment Summary (HEAST) for
Chlorobutane, 1-
CAS: 000109-69-3
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Summary of HEAST Information on-Line
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| Subchronic and Chronic Toxicity |
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|
|
|
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
|
| Subchronic [RfD]: |
9E-1 mg/kg/day |
| Uncertainty Factor: |
100 |
|
| Route: |
Oral: gavage |
|
| Target Organ / Critical Effect: |
Whole body / Decreased weight gain |
|
Central nervous system / Effects |
|
Spleen / Hematopoiesis |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
NOAEL |
86 mg/kg/day |
13 weeks |
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| References |
| 1986 | NTP (National Toxicology Program). 1986. Toxicology and carcinogenesis studies of n-Butyl Chloride in F344/N rats and B6C3F1 mice (gavage studies). CAS No. 109-69-3. NTP-TR-312, 198 p. |
| 1988 | U.S. EPA. 1988. Health and environmental effects document for Monochlorobutanes. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
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|
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| Chronic [RfD]: |
4E-1 mg/kg/day |
| Uncertainty Factor: |
100 |
|
| Route: |
Oral: gavage |
|
| Target Organ / Critical Effect: |
Whole body / Increased mortality |
|
Central nervous system / Effects |
|
Blood / Hematologic effects |
|
| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
NOAEL |
43 mg/kg/day |
103 weeks |
|
| References |
| 1986 | NTP (National Toxicology Program). 1986. Toxicology and carcinogenesis studies of n-Butyl Chloride in F344/N rats and B6C3F1 mice (gavage studies). CAS No. 109-69-3. NTP-TR-312, 198 p. |
| 1988 | U.S. EPA. 1988. Health and environmental effects document for Monochlorobutanes. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
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