Health Effects Assessment Summary (HEAST) for
Chlorobenzotrifluoride, 4-
CAS: 000098-56-6
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Chronic [RfD]: (see comment) |
2E-2 mg/kg/day | |||
| Uncertainty Factor: | 1000 | |||
| Subchronic [RfD]: (see comment) |
2E-1 mg/kg/day | |||
| Uncertainty Factor: | 100 | |||
| Route: | Oral: gavage | |||
| Target Organ / Critical Effect: | Kidney / Tubular degeneration | |||
| Species | Effect Level | Dose | ||
| Rat | NOAEL | 15 mg/kg/day | ||
| References | ||||
| 1981 | Hooker Chemical Corp. 1981. Modified 90-day gavage and reproduction study in rats PCBTF. Conducted by Elars Bioresearch Laboratories, Inc, Fort Collins, CO, U.S. EPA/OPTS public files. Microfiche #OTSO508148. | |||
| 1988 | U.S. EPA. 1988. Health and environmental effects document for 4-Chlorobenzotrifluoride. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC | |||
| Subchronic [RfD] Comments: | Based on a 2-generation reproduction study with exposures 4 weeks prior to mating, during gestation, and for 90 days post-weaning. | |||
| Chronic [RfD] Comments: | Based on a 2-generation reproduction study with exposures 4 weeks prior to mating, during gestation, and for 90 days post-weaning. | |||
[ Risk Assessment Home ]
[ EPA Home |
OSWER Home | Superfund Home ]
[ Search EPA
| Search Superfund
| Whats New |
Contact Us ]
URL: http://risk.lsd.ornl.gov/epa/heast/heast_select.htm
This page was last updated on: March 1, 2000
Site maintained by: Office of Emergency and Remedial Response
Hofmann.Lee@epamail.epa.gov