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Health Effects Assessment Summary (HEAST) for

Chlorobenzilate

CAS: 000510-15-6

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:on-Line
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:on-Line
Inhalation [Unit Risk]:on-Line
EPA Group:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 2E-2 mg/kg/day

Uncertainty Factor: 300

Route: Oral: gavage

Target Organ / Critical Effect: Gastrointestinal system / Decreased stool quantity
Whole body / Decreased food consumption
Whole body / Decreased weight gain
Nervous system / Hyperirritability

Species Effect Level Dose Experiment Length
Rabbit NOEL 5 mg/kg/day 13 days

References
1984 Ciba-Geigy Corporation. 1984. MRID No. 00144691. Available from EPA, write to FOI, EPA, Washington, DC 20460.
1991 U.S. EPA. 1991. Health and environmental effects document for Chlorobenzilate. Prepared by the Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Cincinnati, OH for the Office of Solid Waste and Emergency Response.
1989 U.S. EPA. 1989. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD]. Based on a teratology study with exposures during days 7-19 of gestation.





Carcinogenicity
Oral [Slope Factor]: 2.7E-1 (mg/kg/day)-1

Inhalation [Slope Factor]:
(see comment)		2.7E-1 (mg/kg/day)-1


Oral [Unit Risk]: 7.8E-6 (µg/L)-1

Inhalation [Unit Risk]:
(see comment)		 7.8E-5 (µg/m3)-1


Route: Oral: gavage, diet

Target Organ / Cancer: Liver / Hepatoma

Species Experiment Length EPA Group
Mouse 82 weeks B2

References
1968 BRL (Bionetics Research Laboratories). 1968. Evaluation of carcinogenic, teratogenic and mutagenic activities of selected and industrial chemicals. I. Carcinogenic Study. Prepared for National Cancer Institute, Report No. NCI DCCP-C6 1973-1-1. NTIS PB-223-157. P. 17, 27-31, 35, 39, 56-57, 68.
1991 U.S. EPA. 1991. Health and environmental effects document for Chlorobenzilate. Prepared by the Office of Health and Environmantal Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
Inhalation Slope Comment: Absorbance by the inhalation route was assumed to equal oral absorption since there were no pharmacokinetic data to the contrary. See Appendix A-II: Dose Conversions on HEAST.
Inhalation [Unit Risk] Comment: Absorbance by the inhalation route was assumed to equal oral absorption since there were no pharmacokinetic data to the contrary.


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