Health Effects Assessment Summary (HEAST) for
Chlorobenzene
CAS: 000108-90-7
| Summary of HEAST Information on-Line | ||||
| Subchronic and Chronic Toxicity | ||||
| ||||
| Alternative Methods | ||||
|
| Chronic [RfC]: (see comment) |
2E-2 mg/cu m | |||
| Uncertainty Factor: | 10000 | |||
| Route: | Inhalation: intermittent | |||
| Target Organ / Critical Effect: | Liver / Effects | |||
| Kidney / Effects | ||||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | LOAEL | 75 ppm | 120 days | |
| References | ||||
| 1977 | Dilley, J.V. 1977. Toxic evaluation of inhaled Chlorobenzene. NIOSH, DHEW, Cincinnati, OH, Contract 210-76-0126. Cited in U.S EPA, 1985. | |||
| 1989 | U.S. EPA. 1989. Updated health effects assessment for Chlorobenzene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC. | |||
| Chronic [RfC] Comments: | 5E-3 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST). Under review, current number subject to change. | |||
| General Comments: | The subchronic and chronic inhalation [RfC] values were derived from methodology that is not current with the interim inhalation methodology used by the RfD/RfC work group. | |||
[ Risk Assessment Home ]
[ EPA Home |
OSWER Home | Superfund Home ]
[ Search EPA
| Search Superfund
| Whats New |
Contact Us ]
URL: http://risk.lsd.ornl.gov/epa/heast/heast_select.htm
This page was last updated on: March 1, 2000
Site maintained by: Office of Emergency and Remedial Response
Hofmann.Lee@epamail.epa.gov