Health Effects Assessment Summary (HEAST) for
Chloroaniline, 4-
CAS: 000106-47-8
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Subchronic [RfD]: (see comment) |
4E-3 mg/kg/day | |||
| Uncertainty Factor: | 3000 | |||
| Route: | Oral: diet | |||
| Target Organ / Critical Effect: | Spleen / Proliferative lesions | |||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | LOAEL | 12.5 mg/kg/day | 78 weeks | |
| References | ||||
| 1979 | NCI (National Cancer Institute). 1979. Bioassay of p-Chloroaniline for possible carcinogenicity. NCI Carc. Tech. Rep. Ser. No. 189. NTIS PB-295896. | |||
| 1987 | U.S. EPA. 1987. Health and environmental effects document for Chloroanilines. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC | |||
| 1987 | U.S. EPA. 1987. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | The chronic oral RfD was adopted as the subchronic oral [RfD]. | |||
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