Health Effects Assessment Summary (HEAST) for
Chloro-2-Methylaniline, 4-
CAS: 000095-69-2
| Summary of HEAST Information on-Line | ||||||||
| Carcinogenicity | ||||||||
|
| Oral [Slope Factor]: (see comment) |
5.8E-1 (mg/kg/day)-1 | |||
| Oral [Unit Risk]: | 1.6E-5 (µg/L)-1 | |||
| Route: | Oral: diet | |||
| Target Organ / Cancer: | Cardiovascular system / Hemangioma | |||
| Cardiovascular system / Hemangiosarcoma | ||||
| Species | Experiment Length | EPA Group | ||
| Mouse | 18 months | B2 | ||
| References | ||||
| 1978 | Weisburger E.K., A.B. Russfield, F. Homburger, et al. 1978. Testing of twenty-one environmental aromatic Amines or derivatives for long-term toxicity or carcinogenicity. J Environ Pathol Toxicol. 2: 325-356. | |||
| 1986 | U.S. EPA. 1986. Health and environmental effects profile for 4-Chloro-2-methylaniline and 4-Chloro-2-methylaniline Hydrochloride. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. | |||
| Oral Slope Comment: | Based on vascular tumors in mice treated with 4-Chloro-2-Methylaniline Hydrochloride. | |||
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