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Health Effects Assessment Summary (HEAST) for

Chloro-1,3-Butadiene, 2- / (Chloroprene)

CAS: 000126-99-8

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfC]:on-Line
Subchronic [RfC]:on-Line
Alternative Methods
Chronic [RfD]:on-Line
Subchronic [RfD]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfC]: 7E-3 mg/cu m
Uncertainty Factor: 300

Subchronic [RfC]: 7E-2 mg/cu m
Uncertainty Factor: 30

Route: Inhalation

Target Organ / Critical Effect: Olfactory epithelium / Degeneration

Species Effect Level Dose Experiment Length
Rat NOAEL 32 ppm 90 days

References
1988 NTP (National Toxicology Program). 1988. Subchronic inhalation toxicity study of Chloroprene in mice and rats. Conducted by Batelle Pacific Northwest Laboratory, Richland, WA.
1992 U.S. EPA. 1992. RfD/RfC Work Group.





Alternate Methods -- Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]:
(see comment)		 2E-2 mg/kg/day

Uncertainty Factor: 100

Subchronic [RfD]:
(see comment)		 2E-2 mg/kg/day

Uncertainty Factor: 100

Route: Inhalation: intermittent

Target Organ / Critical Effect: Hair / Alopecia
Whole body / Decreased weight gain

Species Effect Level Dose Experiment Length
Rat NOAEL 10 ppm 2 years

References
1985 Du Pont De Nemours and Company, Inc. 1985. 2-year inhalation carcinogenicity study of Chloroprene in rats. EI Du Pont De Nemours and Co., Inc., Wilmington, DE.
1989 U.S. EPA. 1989. Health and environmental effects document for 2-Chloro-1,3-Butadiene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
Subchronic [RfD] Comments: Based on route to route extrapolation assuming an inhalation absorption factor of 0.5.
Chronic [RfD] Comments: Based on route to route extrapolation assuming an inhalation absorption factor of 0.5.


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