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Health Effects Assessment Summary (HEAST) for

Chlordane

CAS: 000057-74-9

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:IRIS
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:IRIS
Inhalation [Unit Risk]:IRIS
EPA Group:IRIS
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 6E-5 mg/kg/day

Uncertainty Factor: 1000

Route: Oral: diet

Target Organ / Critical Effect: Liver / Hypertrophy

Species Effect Level Dose Experiment Length
Rat NOEL 0.055 mg/kg/day 130 weeks

References
1983 Velsicol Chemical Corp. 1983. ACC NO 252267, MRID No. 00138591, 00144313. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
1989 U.S. EPA. 1989. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].





Carcinogenicity
Inhalation [Slope Factor]:
(see comment)		1.3E+0 (mg/kg/day)-1


Route: Oral: diet

Target Organ / Cancer: Liver / Carcinoma

Species EPA Group
Mouse IRIS

References
1973 Velsicol. 1973. Eighteen-month oral carcinogenic study in mice, December 14, 1973. MRID No. 00067568. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
1977 NCI (National Cancer Institute). 1977. Bioassay of Chlordane for possible carcinogenicity. NCI Carcinogenesis Tech Rep Ser No. 8. Also Publ as DHEW Publ No. (NIH) 77-808.
1988 U.S. EPA. 1988. Updated health effects assessment for Chlordane. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC.
1986 U.S. EPA. 1986. Carcinogenicity assessment of Chlordane and Heptachlor/Heptachlor Epoxide. Prepared by the Office of Health and Environmental Assessment, Carcinogen Assessment Group, Washington, DC.
1987 U.S. EPA. 1987. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
Inhalation Slope Comment: Based on route to route extrapolation. See Appendix A-II: Dose Conversions on HEAST.


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