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Health Effects Assessment Summary (HEAST) for

Carbon Tetrachloride

CAS: 000056-23-5

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Carcinogenicity
Oral [Slope Factor]:IRIS
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:IRIS
Inhalation [Unit Risk]:IRIS
EPA Group:IRIS
Notes/Comments:on-Line





Carcinogenicity
Inhalation [Slope Factor]:
(see comment)		5.3E-2 (mg/kg/day)-1


Route: Oral: diet

Target Organ / Cancer: Liver / Tumors

EPA Group
IRIS

References
1961 Della Porta, G.B., B. Terracini and K.P. Shubik. 1961. Induction with Carbon Tetrachloride of liver cell carcinomas in hamsters. J Natl Cancer Inst 26: 855-863.
1942 Edwards, J., W.E. Heston and H.A. Dalton. 1942. Induction of the Carbon Tetrachloride hepatoma in strain l mice. J Natl Cancer Inst 3: 297-301.
1976 NCI (National Cancer Institute). 1976. Report on carcinogenesis bioassay of Chloroform. NTIS PB264-018. NCI-CG-TR-3.
1984 U.S. EPA. 1984. Health assessment document for Carbon Tetrachloride. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH.
1984 U.S. EPA. 1984. Health effects assessment for Carbon Tetrachloride. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC.
1986 U.S. EPA. 1986. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
Inhalation Slope Comment: See Appendix A-II: Dose Conversions on HEAST.


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