Health Effects Assessment Summary (HEAST) for
Carbon Disulfide
CAS: 000075-15-0
| Summary of HEAST Information on-Line | ||||||||||
| Subchronic and Chronic Toxicity | ||||||||||
|
| Subchronic [RfD]: (see comment) |
1E-1 mg/kg/day | |||
| Uncertainty Factor: | 100 | |||
| Route: | Inhalation: intermittent | |||
| Target Organ / Critical Effect: | Fetus / Toxicity | |||
| Species | Effect Level | Dose | ||
| Rabbit | NOEL | 11 mg/kg/day | ||
| References | ||||
| 1981 | Hardin B.D., G.P. Bond, M.R. Sikor, F.D. Andrew, R.P. Beliles and R.W. Niemeir. 1981. Testing of selected workplace chemicals for teratogenic potential. Scand J Work Environ Health. 7(suppl 4): 66-75. | |||
| 1985 | U.S. EPA. 1985. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | The chronic oral RfD was adopted as the subchronic oral [RfD]. | |||
| Subchronic [RfC]: (see comment) |
7E-1 mg/cu m | |||
| Uncertainty Factor: | 30 | |||
| Route: | Inhalation: intermittent | |||
| Target Organ / Critical Effect: | Peripheral nervous system / Dysfunction | |||
| Species | Effect Level | Dose | Experiment Length | |
| Human: occupational | BMC | 19.7 mg/cu m | 12.1 +/- 6.9 years | |
| References | ||||
| 1983 | Johnson B.L., J. Boyd, J.R. Burg et al. 1983. Effects on the peripheral nervous system of workers' exposure to Carbon Disulfide. Neurotoxicology 4:53-66. | |||
| 1995 | U.S. EPA. 1995. RfD/RfC Work Group. | |||
| Subchronic [RfC] Comments: | The chronic inahaltion RfC was adopted as the subchronic inhalation [RfC]. | |||
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