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Health Effects Assessment Summary (HEAST) for

Captan

CAS: 000133-06-2

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:on-Line
Oral [Unit Risk]:on-Line
EPA Group:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 1.3E-1 mg/kg/day

Uncertainty Factor: 100

Route: Oral: diet

Target Organ / Critical Effect: Whole body / Decreased weight

Species Effect Level Dose
Rat NOEL 12.5 mg/kg/day

References
1982 Chevron Chemical Company. 1982. Confidential business information, unpublished study. MRID No. 00125293. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
1982 Stauffer Chemical Company. 1982. Confidential business information, unpublished study. MRID No. 00120315. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
1984 U.S. EPA. 1984. Health and environmental effects profile for Captan. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
1989 U.S. EPA. 1989. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].





Carcinogenicity
Oral [Slope Factor]:
(see comment)		 3.5E-3 (mg/kg/day)-1


Oral [Unit Risk]: 1.0E-7 (µg/L)-1


EPA Group
B2

References
1977 NCI (National Cancer Institute). 1977. Bioassay of Captan for possible carcinogenicity. CAS No. 133-06-2. NTIS PB-273475.
1982 Chevron. 1982. Unpublished study.
1983 Biodynamics. 1983. Submitted Chevron Chemical Corporation. Unpublished study.
1984 U.S. EPA. 1984. Health and environmental effects profile for Captan. Prepared by the Office of Health and Environmental Assessment,Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
1988 U.S. EPA. 1988. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
Oral Slope Comment: Under review, number subject to change.


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