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Health Effects Assessment Summary (HEAST) for

Captafol

CAS: 002425-06-1

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:on-Line
Oral [Unit Risk]:on-Line
EPA Group:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 2E-3 mg/kg/day

Uncertainty Factor: 1000

Route: Oral: capsule

Target Organ / Critical Effect: Kidney / Effects
Bladder / Effects

Species Effect Level Dose Experiment Length
Dog LOAEL 2 mg/kg/day 12 months

References
1985 Ortho-Chevron Chemical Company. 1985. Confidential business information, unpublished study. Accession NO 260671, MRID No. 00149488, 00155196. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
1984 U.S. EPA. 1984. Health and environmental effects profile for Captafol. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
1987 U.S. EPA. 1987. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].





Carcinogenicity
Oral [Slope Factor]:
(see comment)		 8.6E-3 (mg/kg/day)-1


Oral [Unit Risk]: 2.4E-7 (µg/L)-1

Route: Oral: diet

Target Organ / Cancer: Lymphatic system / Lymphosarcoma

Species EPA Group
Mouse C

References
1984 U.S. EPA. 1984. Health and environmental effects profile for Captafol. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
Oral Slope Comment: Under review, number subject to change.


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