HEAST Summary

Health Effects Assessment Summary (HEAST) for
Bromoform

CAS: 000075-25-2

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity

Chronic [RfD]: IRIS

Subchronic [RfD]: on-Line

Chronic [RfC]: IRIS

Carcinogenicity

Oral [Slope Factor]: IRIS

Inhalation [Slope Factor]: on-Line

Oral [Unit Risk]: IRIS

Inhalation [Unit Risk]: IRIS

EPA Group: IRIS

Notes/Comments: on-Line


Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:	2E-1 mg/kg/day
Uncertainty Factor:	100

Route:	Oral: gavage

Target Organ / Critical Effect:	Liver / Effects

Species	Effect Level	Dose	Experiment Length
Rat	NOEL	17.9 mg/kg/day	13 weeks

References
1989	NTP (National Toxicology Program). 1989. Toxicology and carcinogenicity studies of Tribromomethane and Bromoform in F344 rats and B6C3F1 mice (gavage studies). NTP-350.
1989	U.S. EPA. 1989. Health and environmental effects document for Bromoform. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
1987	U.S. EPA. 1987. Health and environmental assessment for Trihalogenated Methanes. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC
1987	U.S. EPA. 1987. RfD/RfC Work Group.


Carcinogenicity

Inhalation [Slope Factor]: (see comment)	3.9E-3 (mg/kg/day)^-1


Route:	Oral: gavage

Target Organ / Cancer:	Intestine, large / Adenomatous polyp
	/ Adenocarcinoma

Species	Experiment Length	EPA Group
Rat	2 years	IRIS

References
1988	NTP (National Toxicology Program). 1988. Technical report on the toxicology and carcinogenesis studies of Trihalomethane (Bromoform) (cas no 75-25-2) in F344 rats and B6C3F1 mice (gavage studies). NTP-TR 350.
1989	U.S. EPA. 1989. Health and environmental effects document for Bromoform. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH, for the Office of Solid Waste and Emergency Response, Washington, DC.
1989	U.S. EPA. 1989. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.

Inhalation Slope Comment:	Based on route to route extrapolation. See Appendix A-II, Dose Conversions on HEAST.

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