HEAST Summary

Health Effects Assessment Summary (HEAST) for
Bromoethene / (Vinyl Bromide)

CAS: 000593-60-2

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity

Chronic [RfC]: IRIS

Subchronic [RfC]: on-Line

Notes/Comments: on-Line

Carcinogenicity

Inhalation [Slope Factor]: on-Line

Inhalation [Unit Risk]: on-Line

EPA Group: on-Line

Notes/Comments: on-Line


Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfC]: (see comment)	3E-3 mg/cu m

Uncertainty Factor:	3000

Route:	Inhalation: intermittent

Target Organ / Critical Effect:	Liver / Hypertrophy
	Liver / Basophilic foci
	Liver / Eosinophilic foci

Species	Effect Level	Dose	Experiment Length
Rat	LOAEL	9.7 ppm	24 months

References
1982	Benya T.J., W.M. Busey, M.A. Dorato and P.E. Berteau. 1982. Inhalation carcinogenicity bioassay of Vinyl Bromide in rats. Toxicol Appl Pharmacol. 64(3): 367-379.
1979	Busey W.M. 1979. Oncogenic potential of Vinyl Bromide during chronic inhalation exposure - rats: Pathology Report. EPA/OTS 8EHQ-0479-0281.
1993	U.S. EPA. 1993. RfD/RfC Work Group.

Subchronic [RfC] Comments:	The chronic inhalation RfC was adopted as the subchronic inhalation [RfC].


Carcinogenicity

Inhalation [Slope Factor]: (see comment)	1.1E-1 (mg/kg/day)^-1


Inhalation [Unit Risk]:	3.2E-5 (µg/m³)^-1

Route:	Inhalation: intermittent

Target Organ / Cancer:	Liver / Tumors

Species	Experiment Length	EPA Group
Rat	2 years	B2

References
1982	Benya T.J., W.M. Basey, M.A. Dorato and P.E. Berteau. 1982. Inhalation carcinogenicity bioassay of Vinyl Bromide in rats. Toxicol Appl Pharmacol. 64: 367-379.
1984	U.S. EPA. 1984. Health and environmental effects profile for Bromoethene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.

Inhalation Slope Comment:	See Appendix A-II: Dose Conversions on HEAST.

[ Risk Assessment Home ]
[ EPA Home | OSWER Home | Superfund Home ]
[ Search EPA | Search Superfund | Whats New | Contact Us ]

URL: http://risk.lsd.ornl.gov/epa/heast/heast_select.htm
This page was last updated on: March 1, 2000
Site maintained by: Office of Emergency and Remedial Response
Hofmann.Lee@epamail.epa.gov