EPA Home PageSuperfund Risk Assessment Home Page


Health Effects Assessment Summary (HEAST) for

Bromodichloromethane

CAS: 000075-27-4

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:IRIS
Oral [Unit Risk]:IRIS
Inhalation [Unit Risk]:IRIS
EPA Group:IRIS





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 2E-2 mg/kg/day

Uncertainty Factor: 1000

Route: Oral: gavage

Target Organ / Critical Effect: Kidney / Cytomegaly

Species Effect Level Dose Experiment Length
Mouse LOAEL 17.9 mg/kg/day 102 weeks

References
1986 NTP (National Toxicology Program). 1986. Toxicity and carcinogenicity studies of Bromodichloromethane in F344/N rats and B6C3F1 mice (gavage studies). NTP tech report, SER No. 321, NIH PUB NO 87-2537.
1987 U.S. EPA. 1987. Health effects assessment for Trihalogenated Methanes. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC
1987 U.S. EPA. 1987. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].


[ Risk Assessment Home ]
[ EPA Home | OSWER Home | Superfund Home ]
[ Search EPA | Search Superfund | Whats New | Contact Us ]
Horizontal Rule
URL: http://risk.lsd.ornl.gov/epa/heast/heast_select.htm
This page was last updated on: March 1, 2000
Site maintained by: Office of Emergency and Remedial Response
Hofmann.Lee@epamail.epa.gov
Horizontal Rule