Health Effects Assessment Summary (HEAST) for
Bis(2-Chloro-1-Methylethyl) Ether
CAS: 000108-60-1
| Summary of HEAST Information on-Line | ||||||||||||
| Carcinogenicity | ||||||||||||
|
| Oral [Slope Factor]: | 7E-2 (mg/kg/day)-1 | |||
| Inhalation [Slope Factor]: (see comment) | 3.5E-2 (mg/kg/day)-1 | |||
| Oral [Unit Risk]: | 2E-6 (µg/L)-1 | |||
| Inhalation [Unit Risk]: | 1E-5 (µg/m3)-1 | |||
| Route: | Oral: gavage | |||
| Target Organ / Cancer: | Liver / Tumors | |||
| Lung / Tumors | ||||
| Species | Experiment Length | EPA Group | ||
| Mouse | 2 years | C | ||
| References | ||||
| 1982 | NTP (National Toxicology Program). 1982. Carcinogenic bioassay of Bis(2-chloro-1-methylethyl) Ether (70%) containing 2-Chloro-1-ethylethyl-(2-chloropropyl) Ether (30%) in B6C3F1 mice (gavage study). NCI Carcinogen Tech Rep Ser No. 239. 105 p. Also publ as DHHS (NIH) 83-1795. | |||
| 1987 | U.S. EPA. 1987. Health and environmental effects document for Haloethers. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. | |||
| General Comment: | Compound tested contained 70% Bis(2-chloro-1-methylethyl)ether and 30% Bis(2-chloroisopropyl)ether. | |||
| Inhalation Slope Comment: | Based on route to route extrapolation (50% respiratory absorption). See Appendix A-II: Dose Conversions on HEAST. | |||
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