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Health Effects Assessment Summary (HEAST) for

Beryllium

CAS: 007440-41-7

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Chronic [RfC]:IRIS
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:IRIS
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:IRIS
Inhalation [Unit Risk]:IRIS
EPA Group:IRIS
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 5E-3 mg/kg/day

Uncertainty Factor: 100

Route: Oral: drinking water

Target Organ / Critical Effect: None observed

Species Effect Level Dose Experiment Length
Rat NOAEL 0.54 mg/kg/day Lifetime

References
1975 Schroeder H.A. and M. Mitchner. 1975. Life-term studies in rats: Effects of Aluminum, Barium, Beryllium and Tungsten. J Nutr. 105: 421-427.
1991 U.S. EPA. 1991. Drinking water criteria document for Beryllium. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Drinking Water, Washington, DC
1985 U.S. EPA. 1985. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].





Carcinogenicity
Inhalation [Slope Factor]:
(see comment)		8.4E+0 (mg/kg/day)-1


Route: Inhalation: occupational

Target Organ / Cancer: Lung / Tumors

Species EPA Group
Human IRIS

References
1980 Wagoner, J.K., P.F. Infante and D.L. Bayliss. 1980. Beryllium: an etiologic agent in the induction of lung cancer, nonneoplastic respiratory disease, and heart disease among industrially exposed workers. Environ Res 21: 15-34.
1987 U.S. EPA. 1987. Health assessment document for Beryllium. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Research Triangle Park, NC.
1988 U.S. EPA. 1988. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
Inhalation Slope Comment: See Appendix A-II, Dose Conversions on HEAST.


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