Health Effects Assessment Summary (HEAST) for
Benzidine
CAS: 000092-87-5
| Summary of HEAST Information on-Line | ||||||||||
| Subchronic and Chronic Toxicity | ||||||||||
| ||||||||||
| Carcinogenicity | ||||||||||
|
| Subchronic [RfD]: (see comment) |
3E-3 mg/kg/day | |||
| Uncertainty Factor: | 1000 | |||
| Route: | Oral: drinking water | |||
| Target Organ / Critical Effect: | Brain / Cellular changes | |||
| Liver / Cellular changes | ||||
| Species | Effect Level | Dose | Experiment Length | |
| Mouse | LOAEL | 2.7 mg/kg/day | 33 months | |
| References | ||||
| 1983 | Littlefield N.A., C.J. Nelson and C.H. Frith. 1983. Benzidine Dihydrochloride: Toxicological assessments in mice during chronic exposure. J Toxicol Environ Health. 12: 671-685. | |||
| 1987 | U.S. EPA. 1987. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | The chronic oral RfD was adopted as the subchronic oral [RfD]. | |||
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