Health Effects Assessment Summary (HEAST) for
Benzenethiol / (Thiophenol)
CAS: 000108-98-5
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Chronic [RfD]: | 1E-5 mg/kg/day | |||
| Uncertainty Factor: | 10,000 | |||
| Subchronic [RfD]: (see comment) |
1E-4 mg/kg/day | |||
| Uncertainty Factor: | 1000 | |||
| Route: | Oral: gavage | |||
| Target Organ / Critical Effect: | Liver / Centrilobular eosinophilic changes | |||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | LOAEL | 0.1 mg/(kg-day) | 90 days | |
| References | ||||
| 1989 | American Biogenics Corp. 1989. Ninety-day gavage study in albino rats using Thiophenol. Prepared by Dynamac Corp of Rockville, MD for the U.S. EPA Office of Solid Waste. | |||
| 1958 | Fairchild E.J. and H.E. Stokinger. 1958. Toxicologic studies on organic Sulfur compounds. 1. Acute toxicity of some Aliphatic and Aromatic Thiols (Mercaptans). Am Ind Hyg Assoc J. 19: 171-189. | |||
| 1993 | U.S. EPA. 1993. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | The chronic oral [RfD] under review by the RfD/RfC workgroup was modified to estimate the subchronic oral [RfD]. | |||
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